Potential Role of UGT1A4 Promoter SNPs in Anastrozole Pharmacogenomics
نویسندگان
چکیده
منابع مشابه
Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics.
Anastrozole belongs to the nonsteroidal triazole-derivative group of aromatase inhibitors. Recently, clinical trials demonstrated improved antitumoral efficacy and a favorable toxicity with third-generation aromatase inhibitors, compared with tamoxifen. Anastrozole is predominantly metabolized by phase I oxidation with the potential for further phase II glucuronidation. It also, however, is sub...
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Anastrozole is an aromatase inhibitor (AI) used as adjuvant therapy for breast cancer. Anastrozole is subject to direct glucuronidation catalyzed by UDP-glucuronosyltransferase1A4 (UGT1A4). Interindividual variability in anastrozole glucuronidation may be affected by UGT1A4 SNPs. Interplay between drug metabolizing genes such as UGT1A4 and transporter genes may also be affected by genetic varia...
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ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2013
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.112.048157